It's apparently considered "meta" to play it that way, though I wouldn't want to. It's been mentioned before that there are too many great POIs about to be tethered to a vendor, but loot and magazines are concentrated in the towns and cities along with POIs, especially with the present RPG dungeon-style POIs, Crack-a-Books, etc., and that's town/city-wide. How would you suggest it be more evenly distributed other than wilderness? I'd think including more POIs in the wilderness might help with that, perhaps even rural stretches of main roadway with housing along the way as opposed to all single, dirt lanes with single cabins, etc., at the end, but not "infinite" maps.
You said more empty space gave you a feeling of aloneness, which I could consider more solitude, peace and quiet time to take in the views, etc., of which I've seen exceptionally few compared to A21 but -- as
Vaeliorin said -- there just aren't many wilderness POIs that are even worth the time. Even Army Post No. 7 used to appear by itself in the wilderness on occasion. Now, it's stuck to town/city grids along with everything else except that occasional cabin (mostly).
Is that what you're suggesting (other than infinite maps)? Just something more going on here and there in the wilderness? Those stretches of housing now and then as opposed to mostly vast, empty space would help, imo.