I tend to perk into the first levels on most things and concentrate on agility tree for the end game. I play SP so I only need to perk into cooking and LoTL once. However, I save everything when I loot (POIs have a lot of crates holding stuff outside of them early game - and even late game when I only have the motorcycle currently and doing T5 POIs).
Current playthrough, non Agility perks - Cooking, LoTL, Miner 69r, Motherload, Junk scrapping, scraping, lockpicking, loot, treasure hunter, cardio, better barter, daring adventures, workstations, mechanic