AI/pathing is huge for me. If that doesn't see serious improvement, I doubt the other additions will make a significant difference to me. No point in modded weapons if the zombie threat doesn't become an actual threat (beyond the cheese that is dog/wolf hordes).
Engine improvements & ragdolls are a close second, I hope it improves combat by reducing stutter and glitchy movement.
Don't really care about more vehicles. I guess running over a zombie or two could be fun, but otherwise they just seem like re-skinned minibikes with some extra storage slots. Having a bike as an intermediate travel option seems good though, but only if the minibike isn't so easy to get anymore (I had it in the first week in all my A16 playthroughs).
I doubt the NPC's & questing in this game will ever come close to being actually interesting. Feels tacked on and way too jokey for any immersion so far, but maybe TFP will surprise me.
Extra POI's will probably make exploring a little more interesting, but unless the whole loot system is reworked alongside it (i.e. you can't get everything by going to the nearest town), I doubt it'll affect me much. Seems like something that could've easily waited till after release, along with the motorbike and jeep.
I just hope they don't break half the game again, and wait another year for fixes.