I actually have three different games going.
One is mostly default settings and is used for multiplayer with family and friends that I have just recently introduced to 7D2D. What isn't default is the days are set to 90 minutes, regular zombies run at night but ferals sprint, airdrops shown on map, max xp sharing radius.
Then there is my quick, solo challenge game that I like to play every once in a while, especially to get my deaths up (otherwise I would never get that Steam achievement). 10 minute day length, maximum nighttime length, nomad, 200% loot, 50% XP, airdrops every 3 days marked on map, BM every night, 64 max zombies, 300% AI block damage normally and on BM, self-imposed rule of permadeath. In this game, I make sure the max zombies is 64 because since the days are so short, it needs to get as many zombies on the screen immediately as it can at the start of each night. I crank up the loot because, if you are lucky, you might be able to get into a single POI per day. Usually though, it takes several days under these settings to complete one (can only be in a POI for a moment before having to go back outside).
Another game is my more serious solo game. 2 hour days, 50% loot, 50% XP, warrior, no airdrops, 32 max zombies, BM with random range 4 -7 no warning, self-imposed rule of permadeath. I have found for normal play, setting the max zombies to 64 is fine but it just means heavier use of explosives. I've recently become tired of that so I've moved to 32... might even take it down to 16.