I simply create goals that I want to achieve in the long run, as well as short term.
When I started my current random gen, I picked out the seed AllOurDestiny. Figured with 12 towns, 3 being hub cities, there was tremendous potential for scavenging as well as simply traveling. But I wanted to focus on building multiple bases that my imagination might create. But aside from just creating, there was plenty of other short term goals to achieve. From tracking down treasure maps, to simply hunting to stock pile more meat. While not always great loot, those treasure maps can bring you some extremely good loot. Before I finally started going to the Traders, I had roughly 60k. After going crazy on reinforced steel and building items you can't craft, I almost went broke. Did a few more maps I had saved, and right now I'm over 100k, and been scavenging for things to sell, mostly gun parts, so I'll have even more Dukes next time I go.
You simply have to find something that motivates you. For me, its creation. And as I continue to learn new tricks, from more than one block deep swimming pools, to creating structures that actually float with complete structural integrity, I just keep thinking about creating something even more bigger, or simply something for fun, like a tower, or a suicide box to fight from on the 7 day horde night, (Though I'm on day 105 (120 minute days), and the only death was because the stupid dead zone clips into the town I was at and I died before I could even react. So I don't count that as a death, that's just bull crap luck lol), so a suicide box I will create will have a lot of thought put into it.
I created a massive island base just south of the main hub city, and at 0.0, built a centralized 4 way at bed rock to house my massive forge (10 forges, 6 cement mixers that yes, I can and have had them running all at the same time), workshop, and garage with more resources than I should have lol. I got lucky, the main hub is just slightly north of 0.0, so I'm not directly under the hub city.
But I made goals to achieve. When I finish the final touches on my current base, my goal is to continue to build various structures. For example, I want to create a massive tower at some point. But my desire is to be as high as I can go before rendering limitation's reduce my scenery.
Yeah, that was long, but if it gives someone ideas, then I guess it was worth the read lol.