Wow, this thread is turning into a very active (and educational --- for me at least) thread.
Weapon wise, I have so far used the gathering tools, bows/knives, and now spears. I have seen my friend use wire cutters and make use of generators and battery banks, powering up his blade traps. I just use spike traps.
I've had the game now for just over 2 years,, and Have never really gone past tier 3 quests, and from watching my friend being sent hither and yon (always over a klick away, it seems like), I just lose interest in the diminishing returns at higher levels. One quest/visit to the trader works for me at first, but not later on, what with no way to increase the number of quests I can 'take' at one time.
Content wise, my friend has been everywhere, done everything, and there is nothing new for him anymore. For me, I can still look forward to those higher tier PoI's, if I get bored. I'm still having fun right now, and Horde Night every night works wonders, getting my guy to 300th level.
Day 39, 0807 hrs...