I have experienced it. It was on Day 2 and it completely disrupted and changed my first week routine. It was a tough challenge to overcome but I did it. I still eat charred meat all the time in the early game and clench my stomach every time I click eat and then feel a relief that I didn’t puke.
I wish there were more random events beyond the player’s control that would cause us setbacks and disruptions to the normal routine. Bad stuff should happen rarely that the player can’t prevent or plan for and can only react to.
The design is not the problem. The problem is that while some players see such things as challenges and emergent objectives, other players see them as a reason to feel anxiety until they happen and then a reason to put the game down if they ever do happen.
I was stressed and worried after it happened but Ingot through it and now I’m my memory it is one of the great stories of early game survival that I have.
One time on war of the walkers mod, right before a horde night on my cabin by a lake, a football team random horde showed up and destroyed all my horde base defense. When horde night hit, and could not fight them all, and spent the entire night swimming and cold in the lake next to my base. That was a good time. Sadly hardly any events like that happen during the vanilla game, i have to mod the game to get stuff like this.
I really wish they would add dynamic harsh weather to the game, like tornadoes and lightning storms, as well as thunder storms that cause the zombies to go into destroy everything rage mode every time loud thunder happens. Tornadoes would be rare but would be an entity that did block damage and left a trail of debris as it moved across the map. They would dissipate 50 meters inside a desert or ice biome.
That would be something else: a tornado hits the day before horde night and your horde base is now gone. What do you do? What Poi is left standing in a condition to fortify? Do you even make a base, or do you just drive around the map until it is over? Granted it would probably be hell to run on a server or record the game though....
Any way, the thing is, the food poisoning mechanic is not that terrible. It's disruptive, but it is not fatal if you know what you are doing. Without the perks you eat canned food until you have enough vitamins, then the vitamins last all day or at least until you need to eat again. with the perk at level 4 there are no more worries. It's not a terrible investment because you also get access to heavy armor and machine gun perks in that same tree.
Now, maybe the real problem is not the food poisoning, but the recipes. Should cooked super corn give food poisoning? Should mushrooms be contaminated even though they live under ground? Wouldn't the grain alcohol in a lot of those recipes make them safe to eat? The vegetable recipes need to have it dialed back a bit, either that or make vitamins craftable. Perhaps add a benefit to beer where it prevents food poisoning but not nearly for as long as vitamins.
And while we are on the subject, food poisoning needs to be BUFFED. It should not be instant. You should get a perk called "just ate", and after that it should kick in. Give the players time to get out and about, and into a fight or trouble so that way when the are down you can kick them in the balls and beat them up with their own football helmet when they are down.