For the updates and such general "linux related tinkering", 7dtd works pretty much flawlessly. There are some linux-specific issues occasionally, like the dynamic music system was broken for a while and the mousewheel scrolling is backwards atm. I haven't run into anything game breaking though.
I run a RTX 2060, Ryzen 5 2600, and 16 gigs of memory, generally fine on any settings, but when the game loads in a couple dozen horde zeds while hosting a friend, I get frames in the 20s. I'm considering getting some more memory since I'm above 12 gig used just from starting the game essentially with a browser open. It doesn't seem to be a real problem, but I can't run any of the bigger overhaul mods.