If you want to survive for any decent amount of time, you're going to want to build your own base or at least heavily modify a poi. For the first blood moon or two, I usually find a cabin somewhere with a loft. Reinforce the doors, build a ladder and knock out the bottom rung. You can camp up top and survive. After that, it's all building. I don't like to get crazy at night until I've surrounded my base with a layer of iron bars jutting out from the top. This keeps the spiders out and works well until the cops start showing up. After that happens, it's all about having upgraded walls and a place to fall back to. That's typically how I do it, anyway.
Also, it doesn't have to be a marriage destroyer. Just invite her to play in your game in split screen. When she inevitably drives your one and only mini bike into the irradiated zone, dies and strands it there, don't stress. Just set up a bedroll close by and slowly work it back, losing all of your wellness in the process. It's just the cost of a happy home!
Not that it's happened to me, though. She does great when she comes into my game! I didn't go from 120 all the way down to 70 or anything! *sobs*