I know some people have trouble with this concept, but if you don't have fun double looting, eating glass, etc.... just don't do it.
I just logged off a bit ago from a new game that will be my last a20 game.
I had intended to find a remnant poi and restore/rebuild it for a base. However, just north of the starting forest trader was a beautiful lake with snowy mountain peaks across on the other side of the lake. With such a beautiful spot, i decided i had to build my own base.
I did one quest. I didn't spam quests, because i was in the mood to explore the town to see what was there, plus loot mailboxes/newspaper stands because i am going to focus archery. I did what i found fun and interesting with absolutely no concern what was optimal.
After exploring for a while, i focused more on resource gathering on the way to my lakeside base location. When i got there, i had enough materials to build a small starter base, get my campfire and forge down, make a cooking pot, and start making bacon and eggs.
I do what i feel like doing and what makes sense in a "what do i need most now to survive in a zombie apocalypse" frame of mind, not in a "what can i do to min/max the game mechanics" frame of mind.
I don't double loot because i find it boring. I don't eat glass because suicide is never the choice for "what do i need most to survive". I learn the things that help me with my survival goals. If i have no current important goals, i choose to do what feels fun, interesting, or rewarding at that particular moment.
I have played since a15. I still find the vanilla game to be my favorite game. I play several of the overhaul mods and enjoy them too, but i play them for a change of pace, not because i find vanilla lacking.
Some people seem to intentionally do things that make the game no longer fun for them. I just don't do that.