As this mod is meant to be a fight for survival, with food and water being scarce, waiting around for zombies to respawn is part and parcel of the challenge. The latest version of the mod is MUCH closer to the A19 version; which took me 3 attempts to clear.
Some tips for you:
Always reseed lootable containers with anything you can find like plant fibres, broken glass, paper etc. As long as the container has one item in it, you will be able to re-loot that container after the respawn timer has expired.
You MUST have loot respawn on for this to work. I'm certain that it would be impossible to complete without it.
Don't start wrenching the "important" items (work lights etc) for things that you will absolutely need to craft the gyro. Maxing out Salvage Operations will be a big help with the number of items you can get from these salvageable blocks. (you get given a wrench after the first quest step, á la A19)
Everything you need to craft the gyro, and any other items that you need to craft can be obtained in the tower, but planning is key. Game stage and loot stage can play a factor in this, so if you don't need to loot it, leave it until you do.
Obtaining oil and acid in this challenge has always been ... well, a challenge, BUT the ability to find acid has been improved, the ability to craft acid has been added, and the recipe for oil has been lowered drastically. The challenge is no longer impossible, but it is a grind. (the Wasteland Treasures book for acid from med cabinets is now a quest reward too)
Levelling can get a bit stale, waiting around for zombies and such, but Screamer farms are totally within the rules - craft up a bunch of campfires, fuel them up with wood and let them burn - before long you'll have so many zombies you won't know what to do with them all
If you can wait to raid the main loot room - wait. Again, game stage and loot stage matters here. If you don't need it, don't get it.
Hunger and thirst can be a real problem in the first few days, but there are so many farm plots in the new tower, and a lot more outside if you want to build a bridge to them, that you should be able to get a farm going fairly easily - as long as RNG is on your side with crop foods. If you get lucky with working vending machines, there should be eggs too
Infection can be a real issue, so firstly - don't get hit! Secondly, nurses have a chance to give antibiotics on harvesting them, so harvest those dead undead nurses, and check your working vending machines for honey ...
I'm looking forward to giving this a proper play through, as I'm one of the guys who made the changes